Isothermal chemistry, engineered for the point of care.
AscellaOne is built on single-temperature isothermal nucleic acid amplification originating in the laboratory of Prof. Eric Kool at Stanford University, combined with reagent formulation and device engineering developed in-house.
Isothermal amplification
Nucleic acids are amplified at a single reaction temperature, with no thermal cycling. This makes the chemistry well suited to compact, low-power instruments.
Freeze-dried reagent beads
Reagents are lyophilized inside the cartridge. Our formulation work aims at room-temperature storage and distribution without a cold chain.
Simplified sample preparation
Reaction chemistry designed to reduce or remove nucleic acid extraction steps, for faster and simpler workflows.
Multiplex cartridge
The cartridge is designed to run multiple targets together with an internal control, read by an optical module in the handheld reader.
Proprietary primer design
A thermodynamics-based algorithm generates and ranks primer candidates, shortening assay design cycles.
Connected reader
The reader connects to a smartphone or tablet app over Bluetooth, which guides operation and shows measurement progress.
Built for multiple sample types.
Our reaction chemistry is designed for simplified sample preparation across saliva, nasal swabs, whole blood and stool.
A new target reaches proof of concept in a short time.
Because new targets can be added on the same platform, AscellaOne addresses infectious disease, antimicrobial resistance and veterinary diagnostics.
Marker selection
Define the target gene region from known species or resistance markers.
Primer design
Our thermodynamics-based algorithm generates candidates in a few hours.
Screening & optimization
Around ten candidates are synthesized and evaluated; the top three are tuned.
Formulation
Freeze-dried beads and resuspension buffer are developed and verified.
A broad and growing assay menu.
Amplification demonstrated in internal analytical studies. Not an exhaustive list.
Building the next generation of point-of-care testing, together.
We are seeking development, manufacturing and distribution partners for human IVD and veterinary applications.